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HRT is the medical replacement or supplementation of hormones the body has stopped producing adequately most commonly estrogen, progesterone, and testosterone, though thyroid, DHEA, and cortisol may also be part of a comprehensive program

113 There are multiple pathways by which CMA dysfunction induces senescence, including the generation of DNA damage, cell cycle arrest (expression of p12/Cdkn1a ), and lipid accumulation

ROS, including superoxide (O ), hydroxyl radicals (OH ), and hydrogen peroxide (HO), are highly reactive molecules that damage lipids, proteins, and DNA

USP22, Trim13, and Smurf1 can cause extracellular matrix aggregation and promote renal fibrosis